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  • PanExcea™ Performance Excipients

    Maximize quality and efficiency while reducing formulation complexities with PanExcea performance excipients -- manufactured using novel particle engineering technology and featuring homogenous crystalline powders -- from Avantor. 

    Supporting Your Production Needs

    • Improved control over processes and greater efficiency
    • Increased revenues and shorter time to market
    • Increased formulation flexibility
    • Rapid formulation development
    • Enhanced applications performance
    • Enable Quality by Design (QbD) drug formulation initiatives

     

    PanExcea™ Excipients for Immediate Release (IR) Overview   

    Product Name

    Product Composition

    Product Number

    MHC300G

    MCC, HPMC and CPVD

    4489-08

    Legend:

    MCC = microcrystalline cellulose

    HPMC = hydroxypropylmethylcellulose

    CPVD = crospovidone

    All raw materials are cGMP-manufactured, compendial grades and are currently listed in the FDA Inactive Ingredient Guide (IIG List).

    PanExcea performance excipients function as a filler, binder and disintegrant.

    Products are available in 25 kg fiber drums.

     

     

    Enabling IR Formulations 

    PanExcea performance excipients are optimized to facilitate efficient manufacturing of immediate release drug formulations using direct compression. The products may be directly formulated with all classifications of Active Pharmaceutical Ingredients (API’s) and accommodate dilution with, or addition of, auxiliary excipients as needed. And they are residual solvent and Bovine Spongiform Encephalopathy (BSE) free.  

    PanExcea™ Excipients IR Excipient Typical Properties

    Characteristics MHC300G
    True Density 1.5238 g/cc
    Angle of Repose Less than 35 degrees
    Flowability Index Greater than 85
    Compressibility Less than 20%
    Hauner Ratio Less than 1.25
    D50 115 µm

     

    PanExcea for Orally Disintegrating Tablets (ODT) Overview 

    Product Name

     

    Product Composition

    Product Number

    MC200G

    Mannitol and Calcium Silicate

    4493-08

    PanExcea ODT performance excipient function as an ODT building block for use in the formulation of an ODT or chewable tablet. All raw materials are currently listed in the FDA Inactive Ingredient Guide (IIG) List).

    Products are available in 25 kg fiber drums.

     

    Enabling ODT Formulations 

    J.T.Baker® brand PanExcea™ ODT performance excipients are optimized to facilitate the efficient and cost-effective manufacturing of orally disintegrating tablets. PanExcea™ ODT acts as a building block that enables the rapid disintegration of a tablet, in the oral cavity without water, while providing excellent mouthfeel. The products may be directly formulated with all classifications of Active Pharmaceutical Ingredients (API’s) and accommodate dilution with, or addition of, auxiliary excipients as needed. And they are residual solvent and Bovine Spongiform Encephalopathy (BSE) free. 

    Characteristics   MC200G
    Bulk Density 0.64 g/cc
    Loss on Drying Less then 6%
    Angle of Repose Less than 35 degrees
    Flowability Index Greater than 85
    Compressibility Less than 20%
    Hauner Ratio Less than 1.35
    D50 103 μm